Sinead Greally is a postdoctoral fellow in the Steen Lab at Boston Children’s Hospital, where she researches neurodegenerative diseases with a focus on synucleinopathies. She earned her PhD in Neuroscience from Maastricht University in 2024. She specializes in mass spectrometry-based proteomics to investigate the molecular mechanisms underlying Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. Her research explores the proteomic landscape of these disorders, identifying potential therapeutic targets and biomarkers in brain tissues and biofluids to uncover disease-specific signatures and proteome differences, including those associated with GBA-linked Parkinson’s disease. She integrates data from proteomics with cell models to study the functional significance of synuclein aggregation, its impact on cellular dysfunction, and its role in disease progression to identify novel therapeutic strategies.
Publications
Dementia with lewy bodies patients with high tau levels display unique proteome profiles
Systems Biology Analysis of Synucleinopathies
Lab Website: Steen Lab









































