Daniele Mattei is a postdoctoral fellow in the Raj Lab, at the Nash Family Department of Neuroscience within the Icahn School of Medicine at Mount Sinai Hospital in New York. Daniele earned his PhD in medical neurosciences from Charite University Hospital in Berlin, Germany, where he focused on microglia and monocyte cell biology and neuroinflammation in neuropsychiatric diseases. Daniele’s research aims at characterizing myeloid cell dysfunctions in relation to idiopathic and GBA-mediated Parkinson’s diseases. Leveraging on patient-derived primary myeloid cells, Daniele integrates multi-omics approaches with cellular functional profiling to understand how common and rare Parkinson’s risk variants affect myeloid cells and contribute to the pathophysiology of Parkinson’s diseases, with the goal of finding immune-targeted pharmacological strategies.

Publications

Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment

Microglia undergo molecular and functional adaptations to dark and light phases in male laboratory mice

Lab Website: Raj Lab