Publications

Below is a select list of papers published by Silverstein Fellows on GBA or GBA related topics.

Long-Term Motor and Cognitive Outcome of Deep Brain Stimulation in Patients With Parkinson Disease With a GBA1 Pathogenic Variant

Silverstein Authors: Alberto Imarisio, Enza Maria Valente

Link: https://pubmed.ncbi.nlm.nih.gov/41124650/

Integrated Stress Response Signatures Drive Monocyte Dysfunction in GBA1- and LRRK2-Linked Parkinson’s Disease

Silverstein Authors: Daniele Matei, Oriol Narcis, Casey Young, Rachel Saunders Pullman, Taufique Raj

Link: https://www.medrxiv.org/content/10.1101/2025.10.08.25337448v1.article-info

Therapeutic Nanobody Development for Targeting α-Synuclein Aggregation in Parkinson’s Disease, with Focus on Parkinson’s Disease with GBA Mutation

Silverstein Authors: Areej Mesleh, Omar El-Agnaf

Link: https://elmi.hbku.edu.qa/en/projects/therapeutic-nanobody-development-for-targeting-%CE%B1-synuclein-aggreg/

Inhibition or genetic reduction of ASAH1/acid ceramidase restore α-synuclein clearance in mutant GBA1 dopamine neurons from Parkinson’s patients

Silverstein Authors: Manoj Kumar, Ricardo Feldman

Link: https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddaf166/8321974?login=false

Commander complex regulates lysosomal function and is implicated in Parkinson’s disease risk

Silverstein Authors: Georgia Minakaki, Bernabe Bustos, Dmitri Krainc

Link: https://www.science.org/doi/10.1126/science.adq6650

Understanding and predicting vascular dementia: Prognostic biomarkers of neuropathology and behavioural impairment in a novel mouse model combining β-amyloidoisis and Gba1 genetic risk

Silverstein Authors: Irina Alecu, Steffany Bennett

Link: https://alz.confex.com/alz/2025/meetingapp.cgi/Paper/107456

Precision Medicine in Parkinson’s Disease

Silverstein Authors: Gadi Maayan Eshed, Roy Alcalay

Link: https://www.neurologic.theclinics.com/article/S0733-8619(24)00106-3/abstract

GBA1-and LRRK2-directed Treatments: The Way Forward

Silverstein Authors: Gadi Maayan Eshed, Roy Alcalay

Link: https://www.prd-journal.com/article/S1353-8020(24)00051-8/fulltext

Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer’s disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations

Silverstein Author: Daan Van Kruining

Link: https://www.sciencedirect.com/science/article/pii/S0969996125001391

Classification of GBA1 Variants in Parkinson’s Disease: The GBA1-PD Browser

Silverstein Authors: Jeffrey Kim, Ziv Gan Or

Link: https://movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1002/mds.29314

The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers

Silverstein Authors: Shachar Shani, Roy Alcalay

Link: https://journals.sagepub.com/doi/10.1177/1877718X241310722?utm_source=researchgate.net&utm_medium=article

Plasma glucosylceramide levels are regulated by ATP10D and are not involved in Parkinson’s disease pathogenesis

Silverstein Authors: Ziv Gan Or, Roy Alcalay

Link: https://pubmed.ncbi.nlm.nih.gov/39371176/